8/17/2023 0 Comments Nature geneticsWithin-sibship GWAS improve estimates of direct genetic effects. Comparing within- and between-family polygenic score prediction. Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits. Genetic predictors of participation in optional components of UK Biobank. Genetic analyses identify widespread sex-differential participation bias. Collider scope: when selection bias can substantially influence observed associations. Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population. The UK Biobank resource with deep phenotyping and genomic data. Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Exome sequencing and analysis of 454,787 UK Biobank participants. Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates. Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants. Recent ultra-rare inherited variants implicate new autism candidate risk genes. Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism. The mutational constraint spectrum quantified from variation in 141,456 humans. Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia. 10 years of GWAS discovery: biology, function, and translation. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Emerging methods and resources for biological interrogation of neuropsychiatric polygenic signal. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Rare coding variants in ten genes confer substantial risk for schizophrenia. Copy number variation and psychiatric disease risk. Finding the missing heritability of complex diseases. The state of the science in psychiatric genomics. Transethnic genetic-correlation estimates from summary statistics. C., Asian Genetic Epidemiology Network Type 2 Diabetes Consortium, Ye, C. Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations. Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power. The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study. Comparative genetic architectures of schizophrenia in East Asian and European populations. Genetic analyses of diverse populations improves discovery for complex traits. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Genetic misdiagnoses and the potential for health disparities. China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up. Overview of the BioBank Japan Project: study design and profile. Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Prioritizing diversity in human genomics research. Translating insights from neuropsychiatric genetics and genomics for precision psychiatry. Psychiatric genomics: an update and an agenda. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Genome-wide association study identifies 30 loci associated with bipolar disorder. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. We discuss recent advancements in the field that will improve the explanatory and predictive power of genetic data and ultimately contribute to improving the management and treatment of patients with a psychiatric disorder. In this Perspective, we highlight ten challenges for the field of psychiatric genetics, focused on the robust and generalizable detection of genetic risk factors, improved definition and assessment of psychopathology and achieving better clinical indicators. However, there are several challenges that must be addressed before genetic findings can be translated into the clinic. There is optimism that genetic findings will pave the way to precision psychiatry by facilitating the development of more effective treatments and the identification of groups of patients that these treatments should be targeted toward. Genome-wide association studies have identified hundreds of robust genetic associations underlying psychiatric disorders and provided important biological insights into disease onset and progression.
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There are quite a few examples of the impact and influence of these albums, from the underground to the very top of the mainstream. High Top Mountain is also Sturgill’s straightforward traditional country record, which curries it even more favor with country listeners. But High Top Mountain and it’s reception is what set the table for Sturgill’s remarkable rise, which in turn set the table for Tyler Childers, Chris Stapleton, Zach Bryan, and so on and so forth. In terms of independent country and roots music, this is like lightning striking three times in the same spot, or as uncanny as Dolly Parton writing “Jolene” and “I Will Always Love You” on the same day (yes, that really happened too.) Granted, most would point to Sturgill Simpson’s album Metamodern Sounds in Country Music as his most remarkable work. This is the day that Jason Isbell released his magnum opus Southeastern, Sturgill Simpson released his debut solo album High Top Mountain, and for good measure, John Moreland released what many consider his landmark album as well, In The Throes. But one good one would be 10 years ago this week, on June 11th, 2013. That doesn’t take away from the fact that we have come much farther than some would have ever fathomed.īut where did it all start? What was independent music’s Big Bang? Is there a moment in time we can point back to when the tide began to turn and the momentum shifted to lead us where we are right now? There are a few different moments and theories that folks could forward for sure. There’s also so much more work to do with certain artists still sliding criminally under the radar. Since the actualization of the country music revolution took 10 years or so to happen, it kind of crept up on us and can be hard to appreciate. This is the reality we now live in thanks to one artist after another building upon what artists before them helped start, and all with an independent spirit and commitment to being self-made and doing it apart from the Music Row and corporate radio system. 10 years ago, we could only dream of our favorite artists securing number one records on the country charts, or minting Gold and Platinum singles and albums, or selling out big theaters and even arenas, and headlining huge festivals that rival mainstream ones in attendance. It’s rather remarkable reflecting back 10 years at just how far independent country, roots music, and Americana have come in finding a seat at the table with their mainstream country counterparts. The treatment with a CI in these participants might provide real-world benefits, such as improved orientation in traffic and speech understanding in difficult listening situations. However, speech understanding in noise improves when wearing the CI. Difficulties may remain at frontal locations and on the CI side. Our data suggest that a CI can, to a large extent, restore localization in participants with single-sided deafness. Speech understanding in noise was better with the CI compared to testing without CI, but only at a position where the CI also improved sound localization. In contrast to most previous results, participants were able to localize low-frequency signals, although they localized high-frequency signals more accurately. The comparison with control data showed that participants had particular difficulties localizing sounds at frontal locations and on the CI side. Three participants always pointed to the normal-hearing side, irrespective of the location of the signal. Fifteen out of 18 participants were able to localize signals on the CI side and on the normal-hearing side, although performance was highly variable across participants. In addition, the benefit of the CI in speech understanding in noise was compared to the localization ability. Data were compared to normal-hearing adults aged between 20 and 83. Low- and high-frequency noise bursts were used in the tests to investigate possible differences in the processing of interaural time and level differences. Sound localization was measured separately at eight loudspeaker positions (4°, 30°, 60°, and 90°) on the CI side and on the normal-hearing side. The present study investigated measures of sound localization in participants with single-sided deafness provided with a CI. This ability can potentially be improved with a unilateral cochlear implant (CI). Spatial hearing is crucial in real life but deteriorates in participants with severe sensorineural hearing loss or single-sided deafness. 5Hospital of the University of Berlin, Charité Medical School, Berlin, Germany.4Hearing Therapy Center Potsdam, Potsdam, Germany.3Department of Otolaryngology, Unfallkrankenhaus Berlin, Berlin, Germany.2Faculty of Life Sciences, University of Leipzig, Leipzig, Germany.1Section of Phoniatrics and Audiology, Department of Otorhinolaryngology, University Hospital of Leipzig, Leipzig, Germany. 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